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These include inflammatory and autoimmune diseases such as rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease, fibrotic disorders like hepatic, pulmonary, muscle and adipose tissue fibrosis, cancer particularly through TAMs which mediate immunosuppression and facilitate tumor progression and metastasis, metabolic diseases including obesity-associated adipose tissue inflammation, diabetes and its complications, and neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke, as well as infection ( Figure 4 )

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The transporter and permeability interactions of asymmetric dimethylarginine (ADMA) and L-arginine with the human blood-brain barrier in vitro

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